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The active fraction turned out to be a tripeptide glycine, histidine, lysine bound to a copper ion.1 That observation kicked off five decades of research

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[2] That work reported a long half-life on the order of 159195 hours (about 78 days) consistent with once-weekly dosing, and it provided the first human safety and tolerability read on the cagrilintide-plus-incretin concept that later became CagriSema

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