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Inhibition of acetate and propionate assimilation by itaconate via propionyl-CoA carboxylase in isocitrate lyase-negative purple bacterium Rhodospirillum rubrum

It can also interact with reduced oxygen species to form hydroxyl radical that inactivates enzymes and disrupts the membranes and organelles 44

6 Previous studies proposed the role of reactive metabolites in methimazole-induced toxicity

placebo in older adults and those results will be forthcoming soon. Premranjan Kumar, Chun Liu, Jean Hsu, Shaji Chacko, Charles Minard and Farook Jahoor, all at Baylor College of Medicine, contributed to this work