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Gasdermin D (GSDMD) is cleaved by activated caspase-1, which results in the formation of membrane holes that promote pyroptosis (Liu et al

In agreement with this positive connection between glutaminolysis and mTORC1, FOXO-mediated expression of GS inhibits mTOR signaling by blocking its lysosomal translocation [76]

The liver is the bodys primary detoxification organ, and glutathione plays a vital role in the livers ability to neutralize and eliminate toxins, free radicals, and waste products

This effect was confirmed in breast cancer cells MCF-7 and MDA-MB-231, further demonstrating the central role of CGA in epigenetic regulation [83]