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Of note, among the most characterized targets of NRF2, haem oxygenase 1 (HMOX1) has been found to be synthetic lethal with FH 8 suggesting that the activation of NRF2 and its downstream targets might have an important prosurvival role in Fh1-deficient cancer cells, beyond the control of redox homeostasis

These drugs received approval for type 2 diabetes management and, in some formulations, chronic weight management

Stem cell neurogenesis replaces neurons in damaged microcircuits and restores neural network functionality

Influenced by diverse chemotactic factors such as C-X-C motif chemokine ligand 1 (CXCL1) and CXCL8, neutrophils adhere to hepatic sinusoidal endothelial cells by binding to vascular cell adhesion molecule 1 and hyaluronic acid, facilitating their migration, ultimately reaching the liver, and exacerbating the inflammatory response (Khan et al., 2023)