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In this study, drug candidates were selected for further analysis if their connectivity scores were lower than 0.8

It is notable that increased Purkinje cell loss is also observed in human subjects with a TMEM106B disease risk allele [190]

Labeled HT-29 cells were pretreated with PBS, PV2, ncAA-nanobody, PV2-PV3 fusion nanobodies and Durvalumab served as positive controls and seeded onto 12-well culture plate at 2 10 5 cells per well (macrophage tumor cell ratio: 1:4)

Additionally, ubiquitination targets HMG-CoA reductase for degradation via the ubiquitin-proteasome pathway, providing another level of regulation