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Gastrointestinal AE with cagrisema were more than with semagutide or cagrilintide monotherapy, however the SAE and AE leading to medication discontinuation were minimal and similar between the groups [87, 90] A programme of phase 3 clinical trials (REDEFINE) assessing the safety and efficacy of cagrisema in people with obesity (NCT05567796, NCT05394519, NCT05813925) is currently ongoing

10.1016/j.brainres.2021.147588 52

Comparative analysis with other antioxidant peptides and molecules suggested that GHK might indicate a higher relative affinity for hydroxyl radical neutralization under laboratory settings

(3) Deng G, Jin L