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Khoo ML, Tao H, Meedeniya AC, Mackay-Sim A, Ma DD

Cancers 8 (7), 63

Mutations in the relevant sites of MTHFR gene can result in a decrease in the enzyme activity of the MTHFR protein, leading to a deficiency of methylenetetrahydrofolate, which can eventually lead to a decrease in the degree of DNA methylation and microsatellite instability, and ultimately can induce colorectal neoplasm [2, 3, 17]