foxo4-dri senolytic peptide animal model 2023 2024 improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells Molecular modelling of the FOXO4-TP53
Molecular modelling of the FOXO4 TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells ScienceDirect The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4 DRI Nature Communications Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging PMC Computational design of peptide targeting FOXO4. a, Domains of FOXO4 Download Scientific Diagram
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