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However, a small number of people reported inflammation at the injection site when sterile water was used to dilute peptides that were supposed to be injected intramuscularly

Concentrations are expressed in micrograms per milliliter

Using the data from 19 case-controlled studies, 5 cross-sectional studies, and 3 prospective studies published before 1995, the meta-analysis of Boushey and colleagues (Boushey et al, 1995) relating basal hyperhomocysteinemia to atherosclerotic vascular disease indicates that, above 10 mol/L, a 5 mol/L increment in circulating homocysteine is associated with a significant increase in the risk of coronary artery disease (60% in men and 80% in women)

Note that people with alcohol dependence may need prescribed thiamine rather than over-the-counter supplements and should seek medical review