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Propafenone promotes mitochondrial HMOX1 expression by activating JNK/JUN signal, induces iron accumulation and ROS eruption, works together with RSL3 to promote ferroptosis in melanoma, Similarly, the CDK4/6 inhibitor palbociclib enhances the efficacy of the ferroptosis inducer auranofin by inducing cell senescence and depleting glutathione (GSH) and NADPH, This suggests that metabolic interventions as a strategy to overcome melanoma heterogeneity ( 6.2 Amplify the therapeutic effect of melanoma by combined targeting of ferroptosis and immune activation Multiple nanoplatforms combine the two functions of metabolic control and immune modulation

Specific abnormalities include high levels of tissue factor, factor VIII, fibrinogen, and inhibitor of plasminogen activator type 1 activity (148)

Delhase, M., Li, N

McManus RM, Latz E