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In the first step, GSH forms an adduct with methylglyoxal (synonyms, 2-oxopropanal and pyruvaldehyde), a potentially toxic byproduct of glycolysis (Chakraborty et al., 2014, Allaman et al., 2015), yielding the glutathione S -conjugate S -d-lactoylglutathione in a reaction catalyzed by glyoxalase I

Laser in situ keratomileusis (LASIK), which damages the stroma, induces expression of COX-2 in the central epithelium and in the keratocytes adjacent to the wound (Miyamoto et al

3b, see Supplementary Fig

According to a recent study [25], enterocytes are the main target cells of SARS-CoV-2 and they respond to the infection by triggering a powerful inflammatory response