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Section 2 synthesizes the pharmacological mechanisms relevant to oral pathologies, focusing on (I) anti-inflammatory and immunomodulatory signaling (e.g., NF-B, COX-2, key cytokines, and macrophage polarization) (II) antioxidant and mitochondrial pathways (e.g., Nrf2/HO-1 activation, ROS scavenging, and redox homeostasis), and (III) antimicrobial and antibiofilm actions (membrane disruption, quorum-sensing interference, and synergy with photodynamic therapy)

Crews and colleagues [148] pioneered this strategy in 2019 by incorporating an ortho-tetrafluoroazobenzene switch into the linker of the VHL-based PROTAC ARV-771, creating photoPROTAC 6 (Fig

[3] This is particularly prominent in patients with antiMDA5 autoantibodies, who are at high risk of developing rapidly progressive interstitial lung disease