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For a 1.6 mg target dose: Volume to Draw = Desired DoseConcentration = 1.6 mg4 mg/mL = 0.4 mL Convert to syringe units

Prior to the acquisition of 1 H-MRS data, first- and second-order B0 shimming within the 1 H-MRS voxel of interest was optimized using the fast automatic shimming technique by mapping along projections (FASTESTMAP) (Tkc et al., 1999, 2009), using an ultra-short TE = 4.6 ms, a mixing time (TM) = 28 ms, TR = 8,200 ms, and 64 averages

Some peptides may be punted to the February 2027 PCAC meeting if the committee determines data are insufficient

Taken together, these changes suggest a return to a normal redox state with normal cellular levels of oxidant flux