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Vitamin B12 is the essential cofactor that lets the Folate Cycle hand a methyl group to homocysteine (via methionine synthase), enabling methionine SAMe production; SAMe is the cell's universal methyl donor Targeting Glutathione Metabolism: Partner in Crime in Anticancer Therapy Glutathione Metabolism an overview ScienceDirect Topics New Insights into the Roles of Cysteine and Homocysteine in Pathological Processes IntechOpen
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