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Finally, in addition to this particular effect [47], there is a direct effect on vasomotor tone (i.e., BPC 157 counteracts both L-NAME-induced hypertension and L-arginine-induced hypotension, and there is a specific activation of Src-Caveolin-1-endothelial nitric oxide synthase (eNOS) pathway [43]

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(D) If an ACO is eligible to receive a prior savings adjustment and the regional adjustment, expressed as a single value as described in 425.656(d), is positive, the ACO will receive an adjustment to its benchmark equal to the higher of the following: ( 1 ) The positive regional adjustment amount