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Ethics declarations Ethics approval and consent to participate This research has been conducted using the UK Biobank Resource under application number 42468 and other large studies and consortia providing publicly available summary statistics

PCD patients can present with symptoms of severe hypoketotic hypoglycaemia, hepatic dysfunction, cardiac arrhythmias, cardiomyopathies or SCD 13,14,15,16,17,18,19

L-arginine: L-arginine is an amino acid that plays a crucial role in immune function and blood vessel health

Pentoxifylline (PTX) Although most of the oral medications investigated for the treatment of PD have shown poor or indeterminate outcomes in controlled studies, PTX has fared much better