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doi: 10.3390/molecules28020835 174

Skipping doses or changing your routine frequently can reduce effectiveness

5-amino-1MQ, an analogue from our initial series of NNMT inhibitors with low IC50 value (IC50=1 M), and high cell membrane permeability (Table 5), produced the greatest reduction of intracellular 1-MNA levels at a concentration of 10 M among tested inhibitors

It is essential to understand the side-effects associated with these medications, and you should always discuss your options with your healthcare provider