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3.3.4 HIF-1 mediated angiogenesis, metastasis and invasion Under hypoxic conditions, HIF-1 regulates a vast set of genes and pro-angiogenic factors both in tumor mass and vascular endothelial cells, including vascular endothelial growth factor (VEGF) (Simon et al., 2008), stromal-derived factor-1 (SDF-1) (Reinmuth et al., 2001)