Potential side effects (usually related to the benzyl alcohol preservative) include: Allergic reactions (rare) Local irritation at injection site In neonates or very small infants, benzyl alcohol can cause toxicity (gasping syndrome) and should NOT be used
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Fortunately, add-on maintenance treatments like Nucala (mepolizumab) are approved by the Food and Drug Administration to treat eosinophilic asthma, a condition where an overproduction of a certain type of white blood cells called eosinophils cause inflammation in the airways and asthma attacks

Warning signs that need medical attention Seek medical evaluation within 24 to 48 hours if you experience: Redness that continues expanding beyond 48 hours after injection Redness diameter exceeding 10 centimeters Increasing pain (not decreasing) after 48 hours Warmth and hardness accompanied by fever above 100.4 F (38 C) Pus, drainage, or fluid oozing from the injection site Red streaks extending outward from the injection site (sign of lymphangitis) Reaction that has not shown any improvement after 7 days Seek emergency medical care immediately if you experience: Hives or rash spreading beyond the injection site to other body areas Swelling of the face, lips, tongue, or throat Difficulty breathing, wheezing, or shortness of breath Dizziness, lightheadedness, or feeling faint Rapid heartbeat Severe abdominal pain These emergency symptoms suggest a systemic allergic reaction (anaphylaxis), which is rare but documented with tirzepatide