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As an example, genetically manipulated models of HD with mouse htt expression provide a unique opportunity for studying evolution of pathogenic processes

doi: 10.1158/0008-5472.CAN-14-1491 207 VaranasiSKChenDLiuYJohnsonMAMillerCMGangulySet al

The impairment of KP in ALS is confirmed by the following evidence: higher serum tryptophan, cerebrospinal fluid (CSF), KYN and QA and a decrease in serum picolinic acid levels in ALS patients