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Biological Trace Element Research , 188

Reduced T3 levels in hypothyroidism impair Na+/K + ATPase regulation, affecting metabolic equivalents and causing symptoms such as fatigue, weight gain, cold intolerance, anxiety, constipation, hypothermia, decreased appetite and locomotion (Reference Kostoglou-Athanassiou and Ntalles1,Reference Fatourechi2)

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Previous studies in STZ-type 1 diabetic rats revealed that ESC also reverses the global loss of H3K9/14 acetylation and H3K4 monomethylation, including at Mmp13/Bmp6 sites, leading to normalization of profibrotic signaling and glomerulosclerosis (Surse et al