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In terms of mechanism, sorafenib blocks the import of cysteine by inhibiting SLC7A11, the subunit of cystine/glutamate antiporter system Xc , thereby triggering ferroptosis and ultimately killing HCC cells (Louandre et al., 2013)

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A chronic (28 days) ammonia exposure in yellow catfish ( Pelteobagrus fulvidraco ) established that the abundance of Flavobacteriaceae , Vibrio , Pseudomonas , Aeromonas and Streptococcus increased in exposed groups showing increased intestinal cell necrosis, lamina propria edema and reduced width of intestinal villi (Luo et al., 2024)