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Acts as a macrophage DAMP molecule like MSU crystals to promote hyperuricemia and its complications ( via NLRP3 inflammasomes in macrophages ( UA activates phagocytosis by macrophages MSU crystals promote phagocytosis by macrophages

Compounding these issues, the adverse side-effects of current drugs are associated with frequent medication changes and high rates of non-adherence to treatment [10]