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Vitamin B12 is naturally found in animal-based foods

The Boolean operators AND, OR were used to combine some of the above terms in the literature search

While the RNI for maintenance is only 1.5 g daily, therapeutic oral doses typically range from: 50-150 g daily for mild deficiency prevention in at-risk groups 1,000-2,000 g daily for treating confirmed deficiency without malabsorption Some formulations contain up to 5,000 g, though there is no proven additional benefit over 1,000-2,000 g for most patients The reason for this dosage discrepancy lies in absorption efficiency

R.O., data analysis and writing the first draft of the manuscript