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PMID: 106 Moreno-IndiasI.Snchez-AlcoholadoL.Prez-MartnezP.Andrs-LacuevaC.CardonaF.TinahonesF.et al

In this model, transient occlusion of the LAD coronary artery, typically around 3060 min, induces ischaemia, followed by reperfusion upon suture removal, activating common mechanisms underlying IRI, such as oxidative stress, calcium overload, mitochondrial dysfunction, and inflammatory responses, similar to human IRI [67]

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This metabolic improvement occurs through AMPK pathway activation and increased NAD+-dependent SIRT1 activity, both of which enhance insulin receptor signaling and glucose metabolism