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b , Nucleic acid scaffold used for RNA extension assays, termed the modified pause scaffold

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Subcutaneous injection bypasses all of these barriers except plasma half-life, which for unmodified small peptides is generally very short (minutes to low hours, based on class-level pharmacokinetic data for similar unmodified peptides)

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Surface chemistry modifications by altering charge density and hydrophobicity have been reported to ameliorate NP toxicity and enhance the efficacy of NPs in biomedical applications (Mout et al., 2012

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