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Rathkopf concluded her presentation with the following key takeaways: Niraparib added to AA + P significantly prolonged time to radiographic progression or death compared with AA + P alone in patients with HRR-mutated mHSPC

The neXtProt knowledgebase in 2020: Data, tools and usability improvements

Thyroid hormone replacement optimization involves tailoring treatment to individual factors, including age, gender, ethnicity, genetics, and comorbidities (15)

Interestingly, despite the activation of caspases in late stages of parthanatos, caspase inhibitors cannot inhibit the parthanatos process except for blocking PARP1 activity, confirming that PARP1-mediated cell death is caspase-independent [137, 139]