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Signal transducer and activator of transcription 3 (STAT3) binds to DNA response elements in the promoters of ferroptosis-related genes (FTH1, SLC7A11, and GPX4) and regulates their expression

The authors acknowledge additional financial support from the UK Department of Health and Cancer Research UK via Experimental Cancer Medicine Center awards to Kings Health Partners/Guys & St Thomas NHS Foundation Trust (JS)

doi: 10.1136/ard-2024-225645 106 WangTZhaoXLiJYinCJiangBXieJet al

In this protocol, we favor a functional definition of SLP dependency as the comparatively limited capacity of malignant cells to sustain long-term proliferation when forced to use OXPHOS-exclusive metabolism (e.g., deprivation of glucose and glutamine, the two primary SLP fuels, at the substrate, transport, or utilization level)