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At these sites, electrons can leak and interact with molecular oxygen, leading to the formation of superoxide, the primary ROS produced in mitochondria

Based on our sequencing data, we propose that activation of phagocytic and endocytic pathways in BAMs may enhance their capacity to phagocytose and degrade A in 5xFAD mice

Results Identification of GPX4 Allosteric Activator In the previous study, we have identified a potential allosteric site in the crystal structure of human GPX4 U46C mutant (hGPX4-C, PDB entry 2OBI