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doi: 10.1016/j.scienta.2015.09.013 13 CaoF.ManmanF.WangR.Diaz-VivancosP.HossainM

An excessive amount of reactive oxygen/nitrogen species (ROS/RNS) leading to an imbalance between antioxidants and oxidants can cause oxidative damage in vulnerable targets such as unsaturated fatty acyl chains in membranes, thiol groups in proteins, and nucleic acid bases in DNA (Ceconi et al