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For the sampled extraction experiments in series, a number of samples are taken from conscious animals by first removing a small amount of blood to a syringe of 0

Methionine plays a role in the biosynthesis of cysteine, carnitine, and taurine (by the transsulfuration pathway), lecithin production, the synthesis of phosphatidylcholine, and other phospholipids

Therefore, to overcome the difficulties of using FXa as a therapeutic substance described above, the FXa polypeptides provided herein are modified to alter the structural capabilities of the polypeptide such that the polypeptides mimic the conformation of the zymogen and are low in null activity in the absence of FVa