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In addition to the unclear clinical efficacy of antioxidants for cancer treatment reported in the literature, there are also issues such as the uncertain toxicity and biosafety of nanomaterials (374, 375), and the uncertain stability and retention time of nanodrug delivery platforms (376)

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Collectively, both the disease itself and the pharmacological treatments have the potential to induce the formation of micronuclei in RA, thereby providing a basis for the generation of cfDNA