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Due to their enrichment in polyunsaturated phospholipids, peroxisomal membranes are highly vulnerable to 4-HNE-induced oxidative damage, which inactivates membrane-associated proteins such as PMP70 and PEX5 and disrupts membrane integrity, giving rise to leaky peroxisomes. The uncontrolled release of ROS and matrix proteins into the cytosol intensifies oxidative stress and, through damaged mitochondriaperoxisome contact sites, impairs fatty acid trafficking and metabolic coordination, thereby aggravating lipotoxic injury in DCM

Studiu 3: Efectele L-Carnitinei asupra Metabolismului

Lysosomal dysfunction and neurodegeneration Lysosomal dysfunction is a prominent pathological hallmark of NDDs

doi: 10.26444/aaem/162732 124 ZelanteT.IannittiR