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The compound does not appear to have carcinogenic activity in the models tested, and its interaction with tumor biology, a legitimate concern given that angiogenesis also supports tumor vascularization, has been examined in several studies without evidence of tumor promotion at physiological doses

PLoS ONE 10:e0125204 Coccurello R, Breysse N, Amalric M (2004) Simultaneous blockade of adenosine A2A and metabotropic glutamate mGlu5 receptors increase their efficacy in reversing Parkinsonian deficits in rats

Analysis system including Lagrangian data assimilation (LaDA) a

Aparicio T, Cozic N, de la Fouchardire C, Meriaux E, Plaza J, Mineur L