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We suggest that reduced GPx1 in monocytes recruited to the gut and intestinal macrophages renders these cells vulnerable to reactive oxygen species-evoked ferroptosis cell death and that unraveling the participation of this pathway in Crohns disease may reveal novel therapeutic approaches to this chronic condition

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National Institute of Neurological Disorders and Stroke (NINDS) - Authoritative resource on traumatic brain injury, stroke, neurodegenerative diseases, and the neuroscience of brain repair mechanisms