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MP-induced autophagy typically exacerbates inflammatory responses, particularly in macrophages, and relies on TLR4 (104, 105)

J Pharmacol Exp Ther (1985) 233(2):51726

Uncertainties and Inconsistencies There are a few uncertainties for consideration: The increase in reactive oxygen species could be the molecular initiating event - while this is true and an increase is ROS is a major contributor and key event to this AOP, proceeding is the event of oxidation of glutathione