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NAPQI is highly reactive and rapidly conjugates with critical cellular enzymes, interfering with normal cellular function and destabilizing the mitochondrial membrane 5

S6a, S6b and S6c)

ALDH activity for 10 M formaldehyde in hepatic mitochondria from individuals with ALDH2*1/*2 was ~ 30% of that from individuals with functional ALDH2*1/*1 [16]

However, our results demonstrate that MSM does affect the response to exercise, with a greater expression of genes driving neutrophil invasion and macrophage activity, suggesting that it may accelerate the initial stages of muscle repair