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27 ChenP.ZhangQ.ZhangH.GaoY.ZhouY.ChenY.et al (2021)

The early loss of thiol levels in asthma may result from the inactivation of various enzymes including -GCS, which plays a key role in maintaining GSH levels (29,30)

Lubos E, Loscalzo J, Handy DE

These bidirectional effects suggest that changes in sex hormone levels, whether physiological, disease-related, or medication-induced, may shift microbial drug-metabolizing capacity in opposite directions in women and men, thereby altering exposure to active drug metabolites [121, 122]