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Another area of increasing interest is the signaling role of astrocytic lactate beyond its role as an energy substrate: emerging evidence demonstrates that lactate induces histone lysine lactylation (e.g., H3K18la), activating transcription factors like Klf4 to regulate genes associated with synaptic plasticity (e.g., Arc, CREB), thereby contributing to epigenetic remodeling during long-term memory formationa mechanism that underscores metabolic signaling as a target for cognitive enhancement (Yao et al., 2023)

Preclinical investigations have also designed a bionic peptide, octadecadienoic acid (CIS-9,12)-FFVLK-FKPHFPKSYTKICQ (OAFF), for treating disc degeneration [441]

Unmasking of glutathione-insulin transhydrogenase in rat liver microsomal membrane

While Se-adequate (0.15 mg Se/kg) also significantly decreased the abundance of Dorea but did not affect the abundance of Turicibacter and Akkermansia 49