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Beyond glucose, local steroids can behave systemically

Nevertheless, the increase in IgA EC 50 at M3 may be explained by the proportion of specific IgA directed against SARS-CoV-2 RBD relative to total systemic IgA decreasing sharply, whereas SARS-CoV-2 anti-RBD IgG levels increased, potentially with an increase in neutralizing activity by somatic hypermutation