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Low MCV is typical of a number of conditions, including: Copper deficiency [2] Iron deficiency [3] Vitamin C deficiency [4] Vitamin B6 deficiency [5] Vitamin A deficiency [6] Anemia of chronic disease [7] Thalassemia [8] Sideroblastic anemia [9] Rheumatoid arthritis [10] Lead toxicity [11] When red blood cells are larger than normal (macrocytic), the MCV is increased

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