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52 78c, as a highly specific and effective CD38 inhibitor, can reverse age-associated NAD + reduction and improve some metabolic and physiological parameters of aging, such as glucose tolerance, cardiac function, muscle function and exercise capacity in both natural aging and accelerated aging mice models

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[67] found that both moderate and severe ME/CFS have reduced mitochondrial function, and severe ME/CFS also have glycolytic impairments with higher rates of respiratory acidification