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Similarly, supplementation with arachidonic acid or other PUFAs can increase cellular sensitivity to ferroptosis ( Figure 2 Lipoxygenases (ALOX) are non-heme iron-containing oxygenases that can directly oxidize PUFAs in cellular membranes to produce lipid peroxides, suggesting that ALOXs may mediate the occurrence of ferroptosis (36)

Through this network-oriented reevaluation, we aim to provide a unifying theoretical perspective that organizes fragmented observations, highlights key regulatory hubs, and generates testable predictions to guide future basic research and the development of potential clinical intervention strategies

"The role of the one-carbon cycle in the developmental origins of Type 2 diabetes and obesity"

Biphasic action of iodine in excess at different doses on ovary in adult rats