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While neither liraglutide nor semaglutide is FDA-approved for cardiovascular protection, research suggests both may help lower the risk of major heart-related events like heart attack, stroke, or cardiovascular death in people with type 2 diabetes

References References Selective and membranepermeable small molecule inhibitors of NNMT Roles of Nicotinamide NMethyltransferase in Obesity and Type 2 Diabetes Nicotinamide Nmethyltransferase inhibition mimics and boosts exercisemediated improvements in muscle function in aged mice Reduced calorie diet combined with NNMT inhibition establishes a healthier gut microbiome in obese mice Kraus et al

This is because issues with regular function of the gastrointestinal tract can prevent the proper release and absorption of the vitamin which causes deficiency