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[32] NTDs occur early in pregnancy (first month), therefore women must have abundant folate upon conception and for this reason there is a recommendation that any woman planning to become pregnant consume a folate-containing dietary supplement before and during pregnancy

doi: 10.1038/s41582-018-0072-1 288 VaciN.KoychevI.KimC.-H.KormilitzinA.LiuQ.LucasC.et al

Therefore, the FOXO1-C/EBP-ATF4 axis not only directly drives proteolysis through the ubiquitin-proteasome system but also indirectly supports these processes by elevating stress response genes like ChaC1 (Oyabu et al., 2022

This drop lines up with slower tissue repair as we get older