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10.1016/j.jor.2018.08.010 3

Tirzepatide (development code LY3298176) is a single engineered peptide a fatty-acid-modified 39-amino-acid molecule that acts as a dual agonist at two incretin receptors: the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor

For sermorelin, the beyond-the-endpoint discussion is mostly hypothetical in adults: proposed effects on sleep quality, body composition, or vitality are mechanistic extrapolations from GH-axis stimulation rather than trial-confirmed outcomes