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Without sufficient NAD+, these enzymes cannot functionwhich explains why the decline in NAD+ with age leads to a cascade of cellular dysfunctions (Katsyuba et al., Nat Metab 2020)

In addition, the Cu + species generated via the Cu 2+ /Cu + redox cycle can act as a peroxidase-mimic (POD-like), catalyzing the conversion of H 2 O 2 into highly cytotoxic OH