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Ethics declarations Competing interests J.M.R has been a paid consultant to Aquestive Pharmaceuticals, Danone Nutricia, Mallinckrodt, Eisai Pharma and Zogenix, and has served on the Scientific Advisory Board of The Charlie Foundation for Ketogenic Therapies (Santa Monica, CA, USA)

Cell free protein synthesis experiments Previous research has shown that the transcription factors GcvR interacts with GcvA when glycine levels are low, preventing GcvA binding to promoter regions found on the gcv operon

Safety Considerations and Who Should Avoid MIC B12 MIC B12 injections are generally well-tolerated when administered by licensed providers, but certain individuals should avoid or use with caution

Human studies are particularly important in determining public health recommendations, especially randomized controlled trials (RCTs) testing well-characterized treatments and applying appropriate statistical analyses