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doi: 10.3390/NU15204486 286 ApostolouAStagosDGalitsiouESpyrouAHaroutounianSPortesisNet al

Beyond these established agents, topical amitriptyline has recently shown promising real-world effectiveness with acceptable tolerability in observational cohorts, yet rigorous randomized evaluations remain warranted to define effect size, optimal formulation, and durability 19

The increased liver levels of acyl-carnitines suggests futile attempts to recycle free CoA from acyl-CoA, and serve as alternative source of energy for brown fat 49 (Extended Data Fig