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FIGURE 4 While spin traps and nitroxides may possess significant therapeutic potential, their clinical applications may be limited by poor bioavailability and targeting and inadequate BBB penetration (mainly due to low lipophilicity)

Carcinogenesis 34 (7), 14421449

Notably, confounding factors, including dietary habits, are often overlooked in most RCTs, but when patients are being enrolled in a study with antioxidant supplementation, baseline antioxidant intake and diet should be evaluated in both partners, male and female